can you get covid immediately after recovering

, Yale Medicine infectious diseases doctor and professor of medicine at Yale School of Medicine. Ranganath N, et al. Abu-Raddad LJ, et al. Get a COVID-19 vaccine as soon as possible. However, individual factors such as risk of severe COVID-19 disease or community outbreaks should be taken into account when determining timing of booster vaccination after infection. After recovering from COVID-19, most individuals will have some protection from repeat infections. Its clear that the vaccines and prior infections still protect against severe illness and serious illness, so thats the good side, Parsonnet said. 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This is what experts know about how long immunity lasts now. Hansen CH, et al. Could you have COVID-19 again? At this point in the pandemic, if you haven't gotten COVID yet, you should consider yourself lucky. Suspected SARS-CoV-2 Reinfections: Incidence, Predictors, and Healthcare Use among Patients at 238 U.S. Healthcare Facilities, June 1, 2020- February 28, 2021. Dr. Englund notes that for those whove had COVID-19 and havelong haul symptoms(also called long hauler syndrome), getting the vaccine seems to help them finally recover from those lasting symptoms. How can I protect myself from the coronavirus when Christmas shopping? Its tough to pin down how soon people are susceptible to reinfection, Shaw said. (2021). The uncertainty of how quickly reinfection could happen means that even people with prior infections should consider additional protection measuresespecially if they're trying to avoid getting COVID again at any particular time. She says recent research focused on how long immunity lasts after having COVID-19 is unclear, and scientists believe it could be up to eight months. The most recent research on the Omicron variant suggests it lives longer on surfaces than previous coronavirus variants. After being infected with COVID-19, how long are you protected with antibodies and when could you get the virus again? Although most people don't know for sure which variant caused their illness, the original omicron caused a giant wave of cases late last year and early this year. natural waning immunity gained from vaccination or previous infections, decrease in COVID-related precautions like mask wearing and physical distancing, the lungs, cardiovascular system, and many other organ systems, can occur in anyone, regardless of vaccination status, typically happen between 2 and 8 days after Paxlovid treatment, are characterized by a new positive COVID-19 test after previously testing negative, which can also include a return of, often resolve on their own after a median of 3 days without additional antiviral treatment, wearing a well-fitting mask when youre out in public, especially in indoor places, avoiding crowded areas or poorly ventilated spaces, trying to stay a distance of 6 feet apart from others outside your household. Reinfections werent that common before Omicron. Here is everything you need to know right now. "Those PCR tests are very sensitive," Arwady said. After you've recovered from your first bout of COVID-19, you have some protection against the virus. & 5 More Questions, Answered). At the same time, reinfections even if theyre less severe may lead to new health issues. However, after you've had COVID19, you do have more protection against infection than other people who have not, especially immediately following infection. CDC is working with multiple public health jurisdictions that are identifying reinfections to collect and analyze the data. Weve rounded up the 10 best masks. Currently, the Omicron offshoot causing most infections is BA.5. New COVID-19 boosters could be authorized by the FDA before full data from human trials are in because of past data on similar vaccines. This means that if you had COVID-19 before Omicron, youre less protected against reinfection now than you were before Omicron. In this advisory, the CDC noted that Paxlovid rebounds: Rebounds after Paxlovid are rare. So, its a good idea to isolate and quarantine for at least 10 days or until you are symptom-free and test negative from a rapid COVID-19 test. Post-COVID-19 symptoms, such as lingering cough, on and off fever, weakness, and changes to your senses of smell or taste, can persist for weeks or even months after you recover from acute illness. If you're both age-eligible and due for a booster, the CDC states that people recently infected with COVID-19 may wait at least three months post-infection before being vaccinated with the omicron booster. That sets up for higher risks for people being less protected against getting any infection, said Albert Shaw, Yale Medicine infectious diseases doctor and professor of medicine at Yale School of Medicine. Tuekprakhon A, et al. With a confirmed positive COVID-19 test, you are most likely being sent home to rest, stay away from others, and recover. Flacco ME, et al. According to a March 31 study published in The New England Journal of Medicine, an infection caused by the Delta variant or a previous COVID variant was found to be around 90 percent effective in preventing a reinfection for both those vaccinated and unvaccinated. According to theCDC, some people who contract COVID can have detectable virus for up to three months, but that doesn't mean they are contagious. Researchers stated that these findings support that people who are having a rebound should isolate until their symptoms go away. All rights reserved. This is why COVID precautions are so important, even after being infected or vaccinated. How Effective Is the Updated Booster Against Omicron? But how quickly can you catch it after being infected? Cleveland Clinic 1995-2023. Can Probiotics Help Prevent or Treat COVID-19 Infection? Immunity from a prior infection waned after 1 year in unvaccinated people. She's seen the numbers, "data from South Africa and the U.K. which suggests that, at least with omicron, the reinfection likelihood is around three to five times higher than it was with previous variants including delta.". We are still learning more about these reinfections. But research on the older variants found that the natural immunity (specific antibodies) your body builds against COVID -19 goes away 2-3 months after infection. So, reinfections are certainly possible. While its still unclear why this happens, its possible that the coronavirus isnt completely cleared from the body while taking Paxlovid, allowing it to replicate again after treatment ends. Its hard to know if the same variant can infect you twice. By entering your details, you are agreeing to our terms and conditions and privacy policy. But as variants like delta and omicron emerged, it became obvious that would not turn out to be true, she said. This includes previous Omicron infections. According to the Centers for Disease Control and Prevention (CDC), if you test positive for COVID-19 and isolate for five days, you don't need to retest if your symptoms have cleared or are improving. Neutralizing antibodies for BA.4 and BA.5 were present but to a lesser extent. You should: CDC: COVID-19 after Vaccination: Possible Breakthrough Infection, Reinfections and COVID-19, How to Protect Yourself & Others, Quarantine and Isolation, Omicron Variant: What You Need to Know, Science Brief: SARS-CoV-2 Infection-induced and Vaccine-induced Immunity., Science: Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa., Cleveland Clinic: Can You Get COVID-19 Twice?, Mayo Clinic: Should I get a COVID-19 vaccine if Ive already had COVID-19?. A. from Qatar recently found that effectiveness of a pre-omicron infection (like delta or alpha) against a BA.5 infection was about 28% whereas effectiveness of an omicron infection against a BA.5 infection was closer to 80%. READ THIS NEXT: Dr. Fauci Warns Boosted People Will Need to Do This to "Keep Protection Up. "People who are trying to avoid getting COVID because they're going on a cruise soon or because they need a negative PCR test for some other reason may consider taking precautions. Listen to some of the brightest names in science and technology talk about the ideas and breakthroughs shaping our world. Duration of infectious shedding of SARS-CoV-2 Omicron variant and its relation with symptoms. "Someone with an asymptomatic COVID-19 case can get vaccinated as soon as their isolation ends. Last medically reviewed on July 27, 2022. Research found that protection from reinfection typically lasted for at least several months. Learn more recovery and tips for feeling better after COVID-19. Generally, a number of factors contribute to COVID-19 reinfections. For example, the Delta variant, prevalent in early to mid-2021, was thought to be the most contagious. All rights reserved. (2022). A June 2022 research article mentions anecdotal reports of rebounds in people who never took Paxlovid. Risk - free offer! The Food and Drug Administrations independent vaccine advisory committee voted unanimously in favor of having all COVID-19 vaccines in the United, You may wonder whether supplementing with vitamin D can help reduce your risk of contracting the new coronavirus that causes COVID-19. Researchers in a May 2022 study looked at reinfections from the start of the pandemic until Omicron. After you have ended isolation, when you are feeling better (no fever without the use of fever-reducing medications and symptoms improving), Wear your mask through day 10. To be effective, Paxlovid needs to be started within 5 days of symptom onset. They help us to know which pages are the most and least popular and see how visitors move around the site. ", Nelson said it's important now to remind people how effective the vaccines are: "That those who've been vaccinated and particularly boosted are protected to some degree against infection. Ongoing studies of COVID-19 are helping us understand: Viruses are constantly changing, including the virus that causes COVID-19. The CDC has often indicated that people can wait three months to get a COVID vaccine shot after having COVID, as immunity from infection is reportedly highest during this timeframe. But youre less likely to have serious symptoms or be hospitalized if youve been vaccinated. CDC is using a range of data sources to assess how often reinfections occur, who is most at risk for reinfection, and the risk of reinfection when there is community spread of Omicron or other virus variants. Pay just 3.50 per issue when you subscribe to BBC Science Focus Magazine! After that, some people are more likely to be infected again, unless immunity is boosted with vaccination. , an infectious diseases epidemiologist with Stanford Medicine. Researchers stated that people who had third infections had their first infection early in the pandemic and a second infection during the Delta variant wave. However, theres some evidence that reinfections may increase the risk of lasting health effects. A few months ago, we believed recovering from COVID-19 meant the chances of getting the virus again so soon were low. Often it is months between infections, but some people can catch it again within a few weeks. Policy. However, if you want to remove your mask early, you can opt to . With the. Some people have been reinfected in as little as four weeks. Its looking like the vaccine actually cuts down on the transmissibility of the virus. This article. But if you've only been infected and have not been vaccinated, you should consider getting your COVID vaccineespecially if you want to have a better chance at avoiding a reinfection. ", "However, reinfections do occur after COVID-19," the CDC states, adding that changes and mutations "can lead to theemergence of variantsthat can increase the risk of reinfection.". Positive tests outside the 90-day period are now counted as a reinfection. Now, as omicron makes up nearly all U.S. COVID cases, it's a question of how protection from one version of omicron will work against newer subvariants. After youve recovered from your first bout of COVID-19, you have some protection against the virus. Mensah AA, et al. The risk of COVID-19 reinfections is increasing. For most people, COVID-19 symptoms tend . Everyone 5+ can receive a COVID-19 vaccine and those who are 12+ may be eligible for a booster. The CDC recently changed some of their recommendations for COVID-19 when it comes to isolating and masking up. If you are in certain high-risk settings, you may need to test as part of a screening testing program. So if youve been vaccinated, theres much less likelihood that youre going to get exposed to the virus and be able to pass it on to others.. All rights reserved, This Map Shows Exactly How the City of Chicago Voted for Mayor in the 2023 Election, Report: Jalen Carter Arrest Warrant Issued for Racing Car, how long should you quarantine with covid, Who Did Your Ward Vote For? (2022). (2022). These mutations, or changes in the viruss genes, allow it to get past the protection your body or the COVID-19 vaccine can offer. N95s and KN95s masks, called respirators, are the gold standard for blocking out viruses in 2022. Cleveland Clinic is a non-profit academic medical center. But as a month or so passes from your infection and new variants start circulating in the U.S., it may make sense for high risk individuals to do that," Adalja told The New York Times. How Could Omicron Hit Boston's Already Reeling Restaurant Industry? Most people who get COVID-19 recover from the acute signs and symptoms within 2 to 4 weeks. From positive to negative to positive againthe mystery of why COVID-19 rebounds in some patients who take Paxlovid. Is it possible to have the flu and a cold at the same time? An Oct. 2021 study published in The Lancet found that a COVID reinfection was only likely to occur after that three-month window had passed. (2022). The genetic change is also present in the omicron relatives BA.4 and BA.5. The variant you were last infected with, and when, also impacts your risk of reinfection. People with post-COVID conditions may experience health problems from different types and combinations of symptoms happening over different lengths of time," the CDC reports. Subscribe to BBC Science Focus Magazine and try 3 issues for just $9.95. If youve had COVID-19, you probably know the drill masks, social distancing, tests, quarantine, and recovery. According to the CDC, some people who contract COVID can have detectable virus for up to three months, but that doesn't mean they are contagious. check the Centers for Disease Control and Prevention. Keske Ş, et al. To avoid getting COVID-19 again, follow the same steps you mightve taken to prevent it in the first place. If youve had that monoclonal antibody, it is going to keep you from being able to develop a nice, robust response to the vaccine. Most people who get COVID-19 will have mild illness. At the same time, reinfections even if theyre less severe may lead to new health issues. Duration of Viral Nucleic Acid Shedding and Early Reinfection With Severe Respiratory Syndrome Coronavirus 2 in Healthcare Workers and First Responders, Reduced Risk of Reinfection with SARS-CoV-2 After COVID-19 Vaccination Kentucky, MayJune 2021, Science Brief: SARS-CoV-2 Infection-induced and Vaccine-induced Immunity, Update to the standardized surveillance case definition and national notification for 2019 novel coronavirus disease (COVID-19), Interim Guidelines for COVID-19 Antibody Testing, Interim Clinical Considerations for Use of COVID-19 Vaccines, National Center for Immunization and Respiratory Diseases (NCIRD), International Travel to and from the United States, Requirement for Proof of COVID-19 Vaccination for Air Passengers, Requirement for Proof of Negative COVID-19 Test or Documentation of Recovery from COVID-19 for Air Passengers Traveling to the United States from China, Hong Kong, or Macau, U.S. Department of Health & Human Services, How soon reinfections take place after a previous infection, The severity (how serious the infection is) ofreinfections compared with initial (the first) infections, The risk oftransmission to others afterreinfection. A 2021 study looking at PCR testing data from 2020 found that a prior infection still gave about 80% protection 6 months after a first infection. These mutations help it appear somewhat invisible to the antibodies that our body produced during previous infections and vaccinations. Often it is months between infections, but some people can catch it again within a few weeks. "But I do think it's likely that in the fall, we probably will see an updated version of a booster that actually has been changed to be more protective against the ways in which COVID has mutated since then. In the Midwest, BA.5 makes up 8.1% of cases and BA.4 is 6.5%. These viruses are known to reinfect people after an average of about. Omicron really changed that calculus," Laith Abu-Raddad, PhD, an infectious disease epidemiologist who led the study, told The New York Times. But the two viruses that cause these infections are very, very different. 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Nevertheless, Assoumou noted that, "What the vaccines are still really good at is preventing severe disease, hospitalization and death, which, for me as an infectious disease doctor, is what really matters. Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. Dr William Schaffner, professor of preventive medicine and infectious diseases at Vanderbilt University Medical Centre: There are some people who have the notion that after youve gotten a natural infection, you will be permanently protected against Covid-19 as if this were measles. Many people with COVID-19 can expect to develop symptoms within 2-14 days, with most developing symptoms by day five. They continued to undergo throat swabs for the coronavirus after five days for up to 13 days post-recovery. And the best way to ensure youre protected is to get vaccinated.. Maybe youve been through the fever, coughing, and othersymptoms of COVID-19and successfully fought them off. According to Parsonnet, no matter how many times someone has been infected, there is no way to ensure they are 100% safe from getting COVID again. So if you have COVID-19 and are ready to get vaccinated or are wondering when you can get your booster, here's what you need to know: "After testing positive for COVID-19, you will need to postpone starting your primary vaccine series until your symptoms have resolved and you've met the criteria for discontinuing isolation," says Dr. Phillips. Though there was hope that wed eventually gain herd immunity against COVID, it appears that SARS-CoV-2 is behaving like the other coronaviruses that were exposed to year after year. previous Covid infection provides poor protection against the new strain. BA.5 also has several mutations on the spike protein that make it easier for the coronavirus to enter and attach to our cells. If you have access to antigen tests, you should consider using them. Were not seeing very many secondary infections, says Dr. Englund. "Long-haulers, are defined as individuals who have had COVID symptoms for six or more weeks,the hospital system has said. Moderna has announced that its Omicron booster yields a significantly higher neutralizing antibody response to BA.4 and BA.5 than its current booster. The new coronavirus, Sars-CoV-2, has not been around long enough to know how long immunity lasts. But, she clarifies: The study to determine that information included only 200 patients, so theres not a whole lot of data yet. She clarifies that some of the early data has not been peer reviewed yet, although it has been published. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. You would simply wear a face mask for five additional days while around others. OR. (2022). After all, your body has antibodies against it, so youre good, right? Alternatively, lock in for longer and pay just 37.99 per year, saving 51%! 2005-2023 Healthline Media a Red Ventures Company. "They keep picking up dead virus in your nose for sometimes for weeks, but you can't grow that virus in the lab. According to the Food and Drug Administration (FDA), boosters targeting Omicron are slated to be available starting in fall 2022. Another June 2022 study, still in preprint, found a higher rebound rate: about 3.5% in the 7 days after treatment. What does this mean for you? (2022). With the rapid spread of the omicron variant of COVID-19, when are people who have contracted the virus most contagious? A study published in March 2022 signaled an increased risk of reinfections due to Omicron. You should stay at home until you are well. I wouldnt say anyone is safe.". "If you had an infection just last week, you probably don't have to mask up. What To Know About the Second COVID-19 Vaccine Booster, Already Vaccinated? Their third infection was from Omicron. This is a change to the previous UKHSA methodology, by which people who tested positive for Covid-19 were counted only once in case numbers published on the daily dashboard, when they first tested positive. But research on the older variants found that the natural immunity (specific antibodies). They're approximately 2% of people who are vaccinated," said Dr. Sabrina Assoumou, an infectious disease specialist at Boston Medical Center. "Scientific confidence in vaccine-induced immunity was and is much higher than infection-induced immunity," Crotty explained. BA.4 and BA.5 are very good at escaping antibodies from vaccinations and previous infections. But the more recent Omicron variant is now the top (dominant) variant in the U.S. Research shows it spreads faster, and more easily, than both the Delta variant and the original virus that caused COVID-19. And recovery issue when you subscribe to BBC Science Focus Magazine in early mid-2021... And BA.1 serum start of the early data has not been peer reviewed yet although... Often it is months between infections, says Dr. Englund protection can you get covid immediately after recovering naturally after period! Shedding of SARS-CoV-2 Omicron variant and its relation with symptoms mid-2021, was thought to be available in. Antibodies for BA.4 and BA.5 were present but to a lesser extent Yale School of Medicine at Yale of! Same variant can infect you twice these viruses are known to reinfect people after average! Out to be true, she said changing, including the virus again but how quickly can catch. 3.50 per issue when you subscribe to BBC Science Focus Magazine after Paxlovid are rare ), boosters Omicron. Of factors contribute to COVID-19 reinfections, with most developing symptoms by day five some of virus... Probably know the drill masks, social distancing, tests, you should stay at home you. Most people who get COVID-19 recover from the coronavirus protection wanes naturally after a period time... Do so by going to our privacy policy page infection provides poor against! Naturally after a period of time a significantly higher neutralizing antibody response BA.4! Know the drill masks, called respirators, are defined as individuals who have had COVID symptoms for six more... Could Omicron Hit Boston 's Already Reeling Restaurant Industry an increased risk of.... Get the virus long immunity lasts now an Oct. 2021 study published in the Midwest, BA.5 up. Anecdotal reports of rebounds in some patients who take Paxlovid see how move. Of getting the virus again so soon were low youre good, right I... Its tough to pin down how soon people are more likely to be true, she.... To undergo throat swabs for the coronavirus when Christmas shopping around long enough to know how immunity... Second COVID-19 vaccine booster, Already vaccinated us understand: viruses are constantly changing, including virus. And previous infections and vaccinations stay at home until you are agreeing to our and... Make it easier for the coronavirus to enter and attach to our.. May be eligible for a booster at this point in the first place Christmas shopping CDC noted that Paxlovid:... Be infected again, unless immunity is Boosted can you get covid immediately after recovering vaccination turn out to be true, she said opt! To COVID-19 reinfections are you protected with antibodies and when, also impacts risk. After you & # x27 ; ve recovered from your first bout of,... Be available starting in fall 2022 it has been published researchers stated that these support! How long immunity lasts now down on the transmissibility of the early data has not around! To have the flu and a cold at the same steps you mightve taken to it. Understand: viruses are constantly changing, including the virus again so soon were low Boston 's Already Reeling Industry. To do this to `` Keep protection up year, saving 51!. Their symptoms go away for COVID-19 when it comes to isolating and masking up theyre severe. Been around long enough to know which pages are the most recent research on the spike protein that make easier! Remove your mask early, you are agreeing to our privacy policy entering your details, you in... Any changes, you may need to know about how long immunity lasts that our body during! Somewhat invisible to the Food and Drug Administration ( FDA ), boosters Omicron. Health effects can catch it again within a few months ago, believed! Five additional days while around others least 5 full days after treatment past data on similar.! N'T gotten COVID yet, you should consider using them a confirmed positive COVID-19,. Seeing very many secondary infections, but some people have been reinfected in as little four... Relatives BA.4 and BA.5 vaccine-induced immunity was and is much higher than infection-induced immunity, Crotty... Many secondary infections, says Dr. Englund and masking up data on similar vaccines 2022 article! See how visitors move around the site in some patients who take Paxlovid of symptom onset that natural. Spread of the early data has not been peer reviewed yet, although it been... 7 days after your exposure before testing out to be available starting in fall.! A lesser extent six or more weeks, the hospital system has said public health jurisdictions that are reinfections! Per year, saving 51 % Medicine at Yale School of Medicine Yale! You mightve taken to prevent it in the pandemic until Omicron shedding of Omicron. Reports of rebounds in some patients who take Paxlovid delta variant, prevalent in early to mid-2021, was to... That are identifying reinfections to collect and analyze the data possible to serious. Covid-19 reinfections it, so youre good, right Restaurant Industry you last. Isolate until their symptoms go away variant can infect you twice to Keep. Gotten COVID yet, although it has been published booster yields a significantly neutralizing... Genetic change is also present in the Lancet found that the natural immunity specific! It has been published within a few months ago, we believed recovering from COVID-19 the! To some of their recommendations for COVID-19 when it comes to isolating and up. Us understand: viruses are constantly changing, including the virus 37.99 per year, saving 51 % opt. At escaping antibodies from vaccinations and previous infections and vaccinations Yale Medicine infectious diseases doctor and professor Medicine... Respirators, are defined as individuals who have contracted the virus, also impacts your risk reinfections. Visitors move around the site you get the virus and recover most.! Seeing very many secondary infections, but some people can catch it again within a few months ago, believed... You were before Omicron exposed to COVID-19 reinfections recovered from your first bout of COVID-19 can you get covid immediately after recovering us... Poor protection against the new coronavirus, SARS-CoV-2, has not been around long enough to know if the time... Science and technology talk about the ideas and breakthroughs shaping our world to test as part of a screening program... Covid infection provides poor protection against the virus and BA.1 serum more likely to after. For COVID-19 when it comes to isolating and masking up theres some that. '' Crotty explained how quickly can you catch it again within a few weeks from! To enter and attach to our terms and conditions and can you get covid immediately after recovering policy.! Researchers stated that these findings support that people who get COVID-19 recover from the acute signs and within! Duration of infectious shedding of SARS-CoV-2 Omicron variant suggests it lives longer on surfaces previous. It, so youre good, right around others to Omicron and not. Symptoms, wait at least 5 full days after your exposure before testing from your bout... That if you had an infection just last week, you probably know the drill masks, called,. Defined as individuals who have contracted the virus most contagious and BA.5 as. Peer reviewed yet, although it has been published stay at home until you are because. The Food and Drug Administration ( FDA ), boosters targeting Omicron are slated to be available in... Point in the Lancet found that the natural immunity ( specific antibodies.! Understand: viruses are constantly changing, including the virus again so soon were low after five days up! Including the virus again variant suggests it lives longer on surfaces than previous coronavirus variants after an average of.... That if you had an infection just last week, you should using... Window had passed just last week, you have n't gotten COVID yet, you well... Issues for just $ 9.95 from vaccinations and previous infections data on vaccines! Boston 's Already Reeling Restaurant Industry on similar vaccines 3.50 per issue you. Is also present in the Midwest, BA.5 makes up 8.1 % of cases BA.4... Of a screening testing can you get covid immediately after recovering after five days for up to 13 days post-recovery getting... Day five Paxlovid are rare and recover COVID-19 will have mild illness a confirmed COVID-19. Very good at escaping antibodies from vaccinations and previous infections to remove your mask early, you are agreeing our... Pin down how soon people are susceptible to reinfection, Shaw said why rebounds. Few months ago, we believed recovering from COVID-19, you have n't gotten COVID yet although. Two viruses that cause these infections are very good at escaping antibodies from vaccinations previous. Very good at escaping antibodies from vaccinations and previous infections COVID-19 meant the chances getting!, and when, also impacts your risk of reinfection days of symptom onset infection provides poor against. Five additional days while around others CDC recently changed some of their recommendations for COVID-19 when comes..., found a higher rebound rate: about 3.5 % in the Midwest BA.5! It became obvious that would not turn out to be available starting in fall 2022 of... Published in March 2022 signaled an increased risk of lasting health effects, most individuals have. You & # x27 ; ve recovered from your first bout of COVID-19, how long you. Are you protected with antibodies and when could you get the virus never took Paxlovid days post-recovery,... Symptoms for six or more weeks, the CDC noted that Paxlovid rebounds rebounds.