Whereas most other biomolecules experience a destructive form of oxidative damage as a result of radiation exposure, melanin remained structurally and functionally intact, appearing capable of producing a continuous electric current that could theoretically be used to produce metabolic energy in living systems. WebIn his book The Science & Myth of Melanin Dr. Timothy Moore states that Melanin is more than just a pigment and is found many areas of the body besides the skin. 8 (August 2004): 656-https://doi.org/10.1111/j.1349-7006.2004.tb03325.x. Buy on Amazon. Apart from the scavenging activity, melanin exhibits other biological activities, including thermoregulatory, radio- and photoprotective, antimicrobial, antiviral, cytotoxic, anti-inflammatory, and immunomodulatory. Hermit93 About the author. In the genus Aspergillus, DHN-melanin has not been identified in some members, as A. nidulans and A. niger. Dopaquinone, a highly reactive intermediate, forms leucodopachrome, which is then oxidized to dopachrome. There are 5 things that the Pineal gland is responsible for: Inner Eye Web A FREE Digital Copy of the Great Book of Melanin Research and The Alkaline Cookbook Access to the Live Weekly Police Stop Law Class. In our studies, it was noted that no melanin pigment production takes place during stationary cultivation of hypermelanized mutant (MEL1) from A. nidulans, indicating that the formation of this pigment involves the oxidative polymerization of the precursors [50]. According to Dr Timothy Moore In humans, melanin is the primary determinant of skin and hair colour The A. auricula melanin displayed inhibitory activity on biofilm formation of the three bacterial strains, E. coli K-12, Pseudomonas aeruginosa PAO1, and P. fluorescens P-3, and there was a proportional reduction in biofilm biomass with the increase in pigment concentration. A state of the art facility which uses disciplined scholarship to ascertain objective knowledge regarding melanin and maintain a database of such knowledge would help to expand the awareness of melanin and its actual characteristics. 22. Medical treatments using radiation such as external beam radiation therapy for cancer patients can damage bone marrow resulting in debilitating side effects. Human hairlessness occurred concurrently with an augmentation in the melanin content of the skin, paving the way for a process called photomelanometabolism.19In what is known as ultrafast internal conversion, melanin can convert 99.9 percent of potentially gene-damaging ultraviolet light into harmless heat, fulfilling both sun blocking and energy-generating functions.20. It was assumed that melanin pigments, participating in redox reactions, are able to perceive the energy of radiation (UV, visible light, and radiation) and convert it into useful reducing power for metabolic processes. Scientists have identified three forms of melanin in humans: eumelanin. Large amounts of agro-industrial residues generated from diverse economic activities have attracted strong industry interest on the utilization of these residues as inexpensive substrates to support the growth of microorganisms in bioprocesses. Book details & editions. What advantages, then, could hairlessness impart? The purpose of this chapter involves a comprehensive discussion of the research on fungal melanin, including the recently discovered biological activities and the potential use of this pigment for several biotechnological applications. Studies have shown that one of the major causes of aging is the surplus free radicals produced during the oxidative metabolism in the human body [108]. A second group of mice was fed white, melanin-poor porcini mushrooms, a third group ate white porcini mushrooms that were supplemented with melanin, and a final control group received no mushrooms or melanin at all. Revitalise Your Life Through Absurdity Therapy, Meditation, Yoga, Grounding & Mindfulness, REGENERATE: Unlocking Your Bodys Radical Resilience Through The New Biology, The New Biophysics of Energy Synthesis: How the Body Harvests Natures Alternative Energy Sources to Power Cellular Pathways, Build Resilience, and Promote Our Evolutionary Edge, https://doi.org/10.1111/j.1349-7006.2004.tb03325.x, https://doi.org/10.2174/1871524915666150203093656, https://doi.org/10.1016/j.mehy.2008.03.038, https://doi.org/10.1016/j.mehy.2015.01.032, https://doi.org/10.1016/j.jenvrad.2007.11.020, https://doi.org/10.1371/journal.pone.0000457, https://doi.org/10.1016/j.bioelechem.2011.04.009, https://doi.org/10.1016/j.taap.2012.08.002, International Journal of Human Nutrition and Functional Medicine, Why Some Scientists Resist the Evidence for Psi, Why Daily Greens are the Real Fountain of Youth, The Power of Peppermint: 15 Health Benefits Revealed. Some melanized fungi have shown to be good candidates for bioremediation of contaminated sites, due to the ability of fungal melanin to bind to heavy metals and radionuclides in contaminated sites. WebIn his book The Science & Myth of Melanin Dr. Timothy Moore states that Melanin is more than just a pigment and is found many areas of the body besides the skin. The evolutionary reason, however, is hard to pin down. 20. 9 (November 2012): 570-76,https://doi.org/10.1089/cbr.2012.1318. In the context, we hope that the information in this book will be useful and will encourage a greater number of researches on fungal melanin, which might be useful to deploy innovative and sustainable solutions for human health and the environment. It has also been reported that melanin thin films possess highly desirable physical and biological properties that make them ideal for organic bioelectronic devices [130]. Melanin is a biological molecule associated with pigmentation in humans and animals. Melanins proposed ability to convert sunlight into metabolic energyakin to the way chlorophyll harvests sunlight in plantsmeans that our species should be reclassified from heterotrophic to photoheterotrophic, and, even more significantly, may raise the prospect that melanin offers protection against ionizing radiationwhiletransforming it into metabolically useful energy. 1: the Great Oracle of Tehuti and the Egyptian System of Spiritual Cultivation by Ra Un Nefer Amen The development of these higher cognitive processes allowed for the materialization of sophisticated technologies, the agrarian revolution, hierarchical social structure, and advanced human civilizations. According to the same authors, the melanin is also an effective vehicle for the transport of boron to cancerous sites in the body, mainly when the cancerous cells to be treated are located in the brain, because this pigment binds boron very strongly. 5 (2007): e457,https://doi.org/10.1371/journal.pone.0000457. Some fungal species produce a dark-brown pigment, known as melanin, by oxidative polymerization of phenolic compounds, such as glutaminyl-3,4-dihydroxybenzene (GDHB) or catechol or 1,8-dihydroxynaphthalene (DHN) or 3,4-dihydroxyphenylalanine (DOPA). Recent studies have shown that in industrial and roadside areas, there is an increase in the proportion of dark melanin-containing fungi, as Cladosporium and Alternaria, which were more resistant to contamination by heavy metals and unsaturated hydrocarbons. WebK12 School Digital and Curricular Classroom Materials - NGL Melanin, the What, the Why and the How: An Introductory Review for Materials Scientists Interested in Flexible and Versatile Polymers. Most Ascomycota fungi synthesize DHN-melanin from the polyketide synthase pathway, whereas few species are able to produce melanin through L-DOPA, in a pathway that resembles mammalian melanin biosynthesis [1113]. They can grow in different culture systems (submerged and solid), and fermentation protocols have been established for large-scale industrial processes. These authors also studied the culture of C. cladosporioides in different growth times and found that a culture grown for two days is not pigmented and has only 34% of Cd adsorption rate that obtained for pigmented biomass after 4 days of growth [155]. The influence of light on intra- and extracellular pigment production was studied in five pigment-producing fungi: M. purpureus, Isaria farinosa, Emericella nidulans, Fusarium verticillioides, and Penicillium purpurogenum [55]. This book, is designed to familiarize the Black Human with Melanin and its importance to life, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. Figure1 shows a general model for fungal dihydroxynaphthalene (DHN)-melanin biosynthesis. [116] showed that Lachnum extracellular melanin (LEM404) had strong anti-ultraviolet radiation activity because the survival rates of Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae under UV radiation were significantly increased after in vitro addition of LEM404. This chapter presents a comprehensive discussion of the research on fungal melanin, including the recently discovered biological activities and the potential use of this pigment for various biotechnological applications in the fields of biomedicine, dermocosmetics, materials science, and nanotechnology. 306 ratings 30 reviews. 2,799 views May 25, 2018 163 Dislike Share REEL NAGAS 28.5K subscribers Order Your Copy of the Great Book of Melanin Research Today!!! 103 pages, Paperback Published September 1, 2001 Studies have shown that it is possible to use melanin as an ultraviolet, visible and near-infrared absorbing pigment in opthalmic devices, protective eyewear, windows, packaging material, umbrellas, canopies, and other similar media suitable for providing protection from radiation [139, 140]. Melanin may also explain another curious fact: that humans are the only species among hundreds of different primates who are almost completely hairless, which is why we are known in biology as the naked ape. Approximately 6 million years ago, the mutation for human hairlessness was introduced into the genome, causing us to diverge from hairy chimpanzee lineages. Watch on QUALIFIED IMMUNITY PACKAGES POLICE STOP/ LAW & GOV FLASHCARDS (PSFC) & (LGFC) Sign up for their newsletter here. :). The Melanin Empath Discover the Knowledge of Melanated Beings Born With Empath Energy Author: Jade Asikiwe Publisher: ISBN: Category: Body, Mind & Spirit Page: 278 View: 702 DOWNLOAD NOW 2020-10-27 in Cindy Sewell The Melanin Empath Survival and Healing Guide to Discover Melanated Beings and Avoid Damage from Negative Energy Author: Cindy Sewell It has been reported that melanin contributes for virulence of C. neoformans, protecting the pathogen against free radicals generated immunologically [29]. This book is designed to familiarize the reader with Melanin and its chemical key to life and ALL living things, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. 4.37. Some studies report that the pigment synthesis requires proper aeration probably related to the oxygen dependency of some enzymatic reactions responsible for the production of pigment. 1: the Great Oracle of Tehuti and the Egyptian System of Spiritual Cultivation by Ra Un Nefer Amen This volume goes over the brain hemispheres, history of religion, Black founders of civilization, the Sun, cosmology and cosmogony, the subjective and objective realms of being, analysis of cosmological system and view of man, spiritual anatomy of man, types of man and the cultivation of the spiritual man, the Tree of Life initiation system, meditation and ritual, oracles, deities, philosophical and psychological foundations, and consulting and interpreting the oracle. The Pineal gland is the first gland developed in your body, and appears in homo-sapiens a mere 3 weeks after conception. In another provocative study published in the journalToxicology and Applied Pharmacology, researchers extracted melanin from the fungusGliocephalotrichum simplexand gave it to mice just before exposing them to gamma radiation, increasing their 30-day survival by 100 percent. It has been reported that various types of peptone, used as a nitrogen source, are able to promote an increase in the production of pigments in many species of fungi [55, 59, 62, 63]. (PDF) melanin melanin Authors: Dr Sumanta Mondal GITAM (Deemed to be University) Abstract Melanin is a natural skin pigment. Rate this book. Melanin is a biological molecule associated with pigmentation in humans and animals. Other dermocosmetic applications of melanins include the use of the pigment for hair dyeing and the development of novel strategies for hair recoloration [150]. Feb 19, 2023. 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